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The agency cited safety risks including potential carcinogenicity, immunogenicity, and concerns about impurities and noted that most of these substances had never undergone rigorous human clinical trials

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Dihexa is an oligopeptide drug derived from angiotensin IV that binds with high affinity to hepatocyte growth factor (HGF) and potentiates its activity at the c-Met receptor

For example, the entry of glutamine through SLC1A5, combined with its exit through the SLC7A5/LAT1 transporter, allows leucine to enter the cell and trigger mTORC1-mediated cell growth