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When NNMT is overactive, it consumes S-adenosylmethionine (SAM) and reduces levels of nicotinamide adenine dinucleotide (NAD+), a critical coenzyme involved in cellular energy production

[3] The proposed mechanism involves B12 altering the gene expression of skin bacteria ( Cutibacterium acnes ), leading to increased inflammatory compounds

Additionally, AOD9604 is particularly advantageous for individuals with metabolic challenges , such as insulin resistance or other conditions that complicate weight management

It was found through preliminary research that treatment with AOD9604 over the course of 14 days in obese mice led to decreased body weight and body fat and was shown to increase the activity of the beta(3)-adrenergic receptors in the fat cells to the same level as those in lean mice