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Acknowledgments The authors would like to thank the biological Science Department of Peking ChipStone for helpful on the figure conduction related to this work Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest

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Layering Considerations: If combining with other research compounds, consider alternating application times (e.g., GHK-Cu in the morning, retinoids at night) or alternating days to avoid overwhelming the skin