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Just note that the bioavailability and effectiveness of oral capsules compared to injections can vary, and further studies are needed to fully understand this

Regulation of WNT5A and WNT11 during MSC in vitro chondrogenesis: WNT inhibition lowers BMP and hedgehog activity, and reduces hypertrophy

Immunohistochemical staining for MMP13, ADAMTS5, and Collagen II in the articular cartilage showed that metformin treatment significantly reduced the MIA-induced upregulation of MMP13 and ADAMTS5, while increasing Collagen II synthesis in the articular chondrocytes (Fig