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This protective effect of supplemented glutathione is attributed to the prevention of membrane fatty acid oxidation, maintenance of average chain length of fatty acids [80], sustainment of high metabolic activity and protection against secondary stress conditions generated as a result of cold treatment [81]

However, when these oxidants accumulate within red cells, hemoglobin and other proteins are oxidized, leading to loss of function and RBC death

Once activated, they express -smooth muscle actin (-SMA) and synthesize collagen, as well as other extracellular matrix proteins, such as fibronectin [11]

Nat Cell Biol 16(12):11801191