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Given that fluoropyrimidine-based therapy will remain a major treatment modality for patients with advanced CRC for the foreseeable future, the need for better, more effective chemotherapy combinations in biologically selected populations to overcome drug resistance is an urgent, unmet need for patients with CRC worldwide

In vitro, we found strong synergistic anti-cancer effects on proliferation and clonogenic capacity, as well as impairment of long-term intrinsic repopulating frequency and self-renewal of NSCLC stem-like cells

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A follow-up reported treated cells divided 44 times versus 34 in controls