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Monitoring markers of dependence like time to first use, nicotine levels, and enjoyment may help identify problematic use

Psychopharmacology 197(3):371377 Xue S, Kallupi M, Zhou B, Smith LC, Miranda PO, George O, Janda KD (2018) An enzymatic advance in nicotine cessation therapy

Aim 3: Develop evidence-based estimates of the major behavioral impacts from FDA tobacco regulatory actions, for the entire US population and for relevant vulnerable populations in the US

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