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A novel thiol compound, N-acetylcysteine amide, attenuates allergic airway disease by regulating activation of NF-kappaB and hypoxia-inducible factor-1alpha

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[PubMed: 25088083] (35 year old Japanese woman developed acute liver injury first noted 14 days after a 2-day course of acetaminophen, cefcapene and loxoprofen which progressed to an acute icteric hepatitis 6 weeks later [peak bilirubin 8.2 mg/dL, ALT 659 U/L, prothrombin index 35%] with ascites and encephalopathy responding to corticosteroids, but ALT elevations persisting with positive lymphocyte stimulation test to acetaminophen only)