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Comprehensive analysis of gut microbial community structural characteristics, metabolite characteristic profiles, and clinical phenotype information promises discovery of critical pathogenic pathways and potential intervention targets (163) Targeted metabolic pathway intervention trials: randomized controlled clinical studies directed at specific metabolic pathways should be designed

When granulosa cells from EMS patients were cultivated in vitro , the levels of Tumor necrosis factor ligand superfamily member(TNF)-, IL-8, and IL-1 in the cell supernatant were greater than in the control group (61)

The potential mechanism involves exerting a protective effect by increasing IL-10 levels and blocking the AMPK/mTOR signaling pathway

Biochem Biophys Res Commun 519:533539 Sun Y, Kang J, Guan X, Xu H, Wang X, Deng Y (2021) Regulation of endoplasmic reticulum stress on the damage and apoptosis of renal tubular epithelial cells induced by calcium oxalate crystals