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A consultation can help set realistic expectations based on your symptoms, health history, and the overall treatment strategy being considered

It was initially planned to recruit 20 analyzable patients (who completed the two-treatment periods) to have 80% power to detect, with a two-sided test at 0.05 significance level, an absolute decrease in percentage over total target of 10% under the A-dopamine period compared with the control (oral l-dopa-alone treatment) period, by assuming a standard deviation of 15% and a within-patient correlation of 0.5 to account for the crossover design

B12 is a water-soluble vitamin with an excellent safety profile

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