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Last reviewed: May 30, 2026 Last updated: May 30, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

Of these, IRS-1 and IRS-2 are the most extensively studied and are known to have overlapping but also distinct biological roles

For example, macrophage-derived Exos induce endothelial ferroptosis and barrier disruption during cerebral ischemiareperfusion injury via thrombospondin-1-mediated binding to OTUD5 and promotion of GPX4 ubiquitination [221]

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