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[2] Oral B12 supplementation generally takes longer to produce effects , with patients often noticing energy improvements within two to four weeks

Baker J, Liu JP, Robertson EJ, Efstratiadis A

In this review, we will focus on the metabolic effects of IGF-1, the concept of metabolic syndrome and its clinical manifestations (impaired lipid profile, insulin resistance, increased glucose levels, obesity, and cardiovascular disease), discussing whether IGF-1 replacement therapy could be a beneficial strategy for these patients

I can feel a sharp 'scratch' when the needle goes in, but it doesn't hurt and I cannot feel the B12 being released into the muscle