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Research Snapshot The Blood-Brain Barrier Problem: The central challenge in neurocognitive research is getting compounds past the blood-brain barrier (BBB), a highly selective membrane that blocks most molecules from entering the brain

Molecular analyses showed that CO23RFLC had acquired a marked increased expression of the MDR1 gene encoding for an efflux pump protein mainly responsible for the drug-resistance, due to a mutation in the transcription factor gene MRR1 [16] whereas CO23RFK had a homozygous mutation (S645Y substitution) in the FSK1 gene, responsible for the synthesis of glucan [17]

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