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232 In addition to HIF-1, SIRT1 regulates other important factors, such as p53, c-Myc, FOXO3, E2F1, BAX, and NF-B

Decreased NAD + levels can contribute to sirtuin mediated deacetylase-dependent alterations in both mitochondrial electron transport activity (resulting in increased production of reactive oxygen species, ROS) as well as to increased nuclear DNA damage leading to the activation poly-ADP-ribose polymerases (PARP)

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