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39 Research indicates that L-GSH shows promise as an effective adjunctive treatment in patients with HIV or TB, and studies have reported L-GSH may also play a potential role in the treatment of other human pathologies that cause a decrease n the levels of GSH, a redox imbalance, and increased levels of TGF-

IF elicits AT stress response via adipocyte-autonomous p53 signalling The most potent mechanisms leading to macrophage recruitment in AT during obesity include stress-related pathways like apoptosis, senescence, and DNA-damage response 3

Given that synapses degrade and protective mechanisms fade as a function of normal ageing, it might be expected that synaptic dysfunction and loss is more pronounced in LLD [242, 243]