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Acknowledgements This work was supported by the Plans for Major Provincial Science & Technology Projects (202303a07020002 to Z.Z.), the National Key Research and Development Program of China (STI2030-Major Projects 2021ZD0203100 to Z.Z.), the National Natural Science Foundation of China (32025017 to Z.Z., 32121002 to Z.Z., 32400824 to P.C., 32522044 to P.C., U24A20702 to P.C.), the Anhui Provincial Natural Science Foundation (2308085QH264 to P.C.), the CAS Project for Young Scientists in Basic Research (YSBR-013 to Z.Z.), the Fundamental Research Funds for the Central Universities (WK9100250108 and WK9100000068 to P.C.), and the USTC Research Funds of the Double First-Class Initiative (YD9100002501 to Z.Z.)

Pentadecapeptide BPC 157, in clinical trials as a therapy for inflammatory bowel diseases (PL14736), is effective in the healing of colocutaneous fistulas in rats: role of the nitric oxide-system