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Low-dose lithium , promoted for brain aging after a 2025 Harvard study showed brain lithium is depleted early in Alzheimers and that lithium orotate reversed pathology in mice, has only mixed human trial evidence and works by dampening neuronal firing, so I do not recommend it for a healthy brain

The endoplasmic reticulum (ER) is essential for the synthesis, folding and transport of proteins

However, someone with decreased intrinsic factor may have symptoms of milder B12 deficiency long before pernicious anemia.[ref] The time to act is long before your body develops full-blown anemia

J Clin Oncol 2021 Gastrointestinal Cancers Symposium 39(3_suppl), 2021