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This extended inhibition window is why once-daily dosing works, but it also means the initial timing sets the metabolic tone for the entire 24-hour cycle

A study in mice showed that specific SCFAs accelerated -syn aggregation and microglial activation, whereas germ-free mice had delayed pathology [95]

Estrogen prevents oxidative damage to the mitochondria in Friedreichs ataxia skin fibroblasts

Our results demonstrate that the core clock protein BMAL1 regulates astrocyte activation and function in vivo, elucidating a novel mechanism by which the circadian clock could influence many aspects of brain function and neurologic disease.