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In respect to PCOS, research has shown Licorice has estrogen activity [107]

Regulation of normal human polyrnorphonuclear leucocytes by carnitine

These are secondary factors, but they explain some of the person-to-person variation people notice

541 Although these approaches facilitate drug design on a technical level, relying on a limited set of known SARs for pharmacophores may somewhat limit the structural diversity of the drugs and narrow the range of targets