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The question of whether Juul can be a stepping stone to traditional smoking remains open, but there is some doubt about this, based on recent evidence that youth smoking rates are steadily declining (the proportion of American teenagers who smoked in the last 30 days decreased from 28.3% in 1996 to 5.9% in 2016)

5 NPC risk factors include a family history of the conditions, use of certain herbal medicines, chronic respiratory tract infections, human leukocyte antigen (HLA) class I genotypes, and occupational exposure to fumes, smoke, dust, or chemicals