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Mapping the growth hormone-Stat5b-IGF-I transcriptional circuit

Sleep disruption changes the microbiome, as is shown in experiments where alterations in gut bacterial profiles were found in mice with circadian rhythm mutations or rats with chronic sleep deprivation ( Several probiotics and prebiotics have been shown to have positive effects on sleep, which could be interpreted to mean that sleep health can be managed by supporting the MGBA (Thompson et al., 2020)