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Increasing nicotine delivery levels in the inhaled aerosol can lead to acceptability issues such as harshness, irritancy, and coughing 17 and this is where aerosolised nicotine salts play a role in reducing irritation, even at high nicotine concentrations

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Additionally, the design of the smoking robot plays a critical role in experimental accuracy, as valve systems within smoke-generating components can interact with cigarette smoke, potentially altering its chemical composition