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67 In contrast to SOD1, SOD2 is inducible by oxidative stress, hyperoxia, environmental pollutants such as cigarette smoke or ozone, and by inflammatory cytokines

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GNDs exerted a selective inhibition of NO generation without interfering with the accumulation of pro-inflammatory agents by disrupting the synthesis of inducible NO synthase in activated macrophages through up-regulation of eIF2 phosphorylation levels, without disturbing Fe homeostasis (Zhang et al., 2022)