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In patients with locally advanced, metastatic, and/or refractory solid tumors and hematological malignancies, CB839 is being evaluated in open-label phase I clinical trials (NCT02071862, NCT02071888, NCT02771626)

Initially created to address visceral fat accumulation in specific medical conditions, it has expanded into applications for recovery and body composition management

Stacking does not multiply the regulatory or safety concerns of either compound but does compound the research-only status of both - neither has FDA or EMA approval, and TB-500 specifically is on the WADA Prohibited List

Diabetes, metabolic syndrome and obesity : targets and therapy