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Currently, silymarin is mainly used as a remedy for Amanita phalloides (death cup fungus) intoxication where silymarin plays a role in hepatoprotection through the mechanisms such as stopping the -amanitin entero-hepatic cycle, prevention of phalloidin and -amanitin binding to membranes of hepatocyte, and antagonising the -amanitin membrane transporting (18,24)

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Zinc is also one of the non-specific elements that contribute to the regulation of cell-mediated immunity and the control of gene expression [98]