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Mediterranean diet The Mediterranean diet (MeD) is a nutritional life style which has been developed and inspired by the dietary traditions of populations living in the Mediterranean Sea area, olive-growing lands, and is characterized by a high consumption of plant-based foods (fruits, cereals, vegetables, nuts, legumes, seeds, and olives), fish and seafood, and moderate amounts of dairy products, meat, and meat products, and of red wine during meals

Mitochondrial dysfunction can activate the mitochondrial unfolded protein response (UPRmt) and integrated stress response (ISR), enhancing cellular stress adaptation and conferring resistance to chemotherapy and targeted therapies [41, 42]

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