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Biology and management of patients with triple-negative breast cancer

Ann New York Acad Sci 1999

[6] Davies, M., et al

Additionally, MTX-glu prevents the conversion of 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) to formaminoimidazole-4-carboxamide ribonucleotide (FAICAR) by inhibiting the key enzyme AICAR transformylase (ATIC) in the purines de novo synthesis pathway, leading to the accumulation of AICAR (Friedman and Cronstein 2019)