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This metabolic downregulation is also important when generating and/or maintaining persister cells, which are transiently dormant, drug-tolerant phenotypes that can reseed biofilms when they are no longer under drug pressure

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(160) indicated that increasing doses of AngIV via the internal carotid artery significantly decreased mortality and cerebral infarct size in rats 24 h following embolic stroke due to the intracarotid injection of calibrated microspheres