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Malathion alters the transcription of target genes of the tumour suppressor tp53 and cancerous processes in Colossoma macropomum : Mechanisms of DNA damage response, oxidative stress and apoptosis

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Metabolic reprogramming driven by oncogenes allows cancer cells to maintain deregulated cell proliferation, withstand metabolic challenges that are associated with diminished oxygen and nutrients, maintain a dedifferentiated state through alterations in global patterns of gene expression, and corrupt the surrounding microenvironment to actively facilitate tumor growth and dissemination 16,17,18

Zheng J, Wang S, Xia L, Sun Z, Chan KM, Bernards R, et al