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A single sharp exposure is all that is needed to trigger the somatotroph release of pre-formed GH, and the downstream effects persist long after the peptide itself has been cleared

Result:The average number of eye-spots (meanSEM) is 5.360.29 (n=46), 7.790.45 (n=34) and 8.780.61 (n=32) in untreated controls, 2 mM L-Buthionine-(S,R)-sulfoximine (BSO) and 20 mM BSO treated mice, respectively

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Methods: A bidirectional Mendelian randomization (MR) study was performed to investigate the causal effects by using 3 main methods (Variance Weighted (IVW), Weighted Median (WM), and MR-Egger regression) in the European population