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CHOP, a member of C/EBP transcription factor family, is an ERS-specific effector molecule representing an important cell transition signal to apoptosis (66)

In addition, the brain is susceptible to oxidative stress because its high in fat, which can oxidize or go rancid. The brain is also high in iron and zinc, which can further fuel oxidative stress

Moreover, our study provides a guide for design of future PPAR agonists that should be screened for lack of inhibition of PGC1 activity

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