glutathione toxicity side effects of Glutathione-Binding Metals: A Review of Targets and Mechanisms Frontiers | Glutathione: A Samsonian

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6.2 NADPH: driving force for glutathione redox cycling The antioxidant activity of glutathione (GSH) critically relies on its regeneration from the oxidized form, glutathione disulfide (GSSG), through a reaction catalyzed by glutathione reductase (GR) that consumes NADPH