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Researchers associate a vitamin B12 deficiency with various health issues, megaloblastic anemia neurological changes and disorders infertility depression neural tube defects and developmental delays in children born to those with a vitamin B12 deficiency Supplementation may help to reduce the risk of these health issues

Similarly, previous work simulating the conditions of Enceladus has demonstrated that the methanogenic archaeon, Methanothermococcus okinawensis , can produce CH 4 when grown in an optimal growth medium, at 5 MPa (Taubner et al., 2018)