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[DOI] [PMC free article] [PubMed] [Google Scholar] [64].Gunawan BK, Liu ZX, Han D, Hanawa N, Gaarde WA, Kaplowitz N

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Because of this, there are several important factors that must be considered when interpreting the results of these studies, including: (1) metabolism of the parent neurosteroid molecule and active metabolites may have a different mechanisms of action

17 A key characteristics of pain related to IC/BPS is that the pain is worsened with bladder filling (painful bladder filling) and/or their strong urge to urinate was due to pain, pressure, or discomfort (painful urgency)