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Although cysteine can be derived from the catabolism of extracellular glutathione, protein catabolism or de novo synthesis from methionine, 12,13,14 the major source of cellular cysteine is the dietary intake of cystine, the oxidised form of cysteine

Tudor et al., 2010) or less severe behavioral disturbances (Jelovac et al., 1998, 1999

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To view the other articles in this section visit Abbreviations MPST 3mercaptopyruvate sulfurtransferase ATF4 activating transcription factor 4 CDO cysteine dioxygenase CSE cystathionine lyase FXR farnesoid X receptor GH growth hormone GPABR1 GPCR for secondary bile acids H 2 S hydrogen sulfide HD Huntington's disease HO2 haem oxygenase 2 Keap1 kelchlike ECHassociated protein 1 mHtt mutant huntingtin NMDA Nmethyl Daspartate Nrf2 nuclear factor (erythroidderived 2)like 2 PLP pyridoxal 5phosphate SAM Sadenosylmethionine SP1 specificity protein 1 Introduction The transsulfuration pathway plays a central role in sulfur metabolism and redox regulation in cells