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A 2024 meta-analysis of 6 randomized controlled trials involving 1,529 women with diminished ovarian reserve found that CoQ10 pretreatment significantly improved clinical pregnancy rates (OR 1.84), increased the number of retrieved oocytes, improved embryo quality, and reduced both cycle cancellation and miscarriage rates ( Lin et al., Annals of Medicine , 2024 )

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GPX4 converts reduced glutathione (GSH) into oxidized glutathione (GSSH) and reduces cytotoxic lipid peroxides