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10.1186/1471-244X-13-196 [DOI] [PMC free article] [PubMed] [Google Scholar] 59.Melnyk S, Fuchs GJ, Schulz E, Lopez M, Kahler SG, Fussell JJ, et al

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extreme caloric restriction may exacerbate menstrual irregularities Micronutrient optimization: Maintain adequate iron intake, particularly if experiencing heavier menstrual bleeding Contraceptive considerations: Discuss alternative contraceptive methods with your provider, as tirzepatide may affect oral contraceptive absorption For women with pre-existing menstrual irregularities or PCOS, tirzepatide treatment may ultimately improve cycle regularity as metabolic parameters normalize