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While both practices involve the inhalation of nicotine, the method of delivery, substances inhaled, and associated health risks significantly differ between the two

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Kiyohara C, Ohno Y: Sex differences in lung cancer susceptibility: a review

(That was the conclusion of an August 2015 Public Health England review of the evidence, which estimated that e-cigarettes are "95 pecent less harmful" than regular cigarettes.) The tougher question is how the long-term impacts of e-cigarettes compare to the long-term impacts of smoking