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It also regulates matrix metalloproteinases (MMPs), particularly MMP-2 and MMP-9, which are involved in extracellular matrix remodeling during tissue repair

However, one study reported that children and adults with normal to elevated levels of serum vitamin B1 had many symptoms normally associated with vitamin B12 deficiency, including fatigue, depression, anxiety, lack of motivation, poor memory, fuzzy thinking, peripheral neuropathy and difficulty sleeping