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Supporting metabolic health is another consideration

Important: These represent findings from controlled animal research studies and limited experimental reports

MOTS-c is a mitochondrial-derived peptide that activates AMPK through direct mitochondrial signaling and nuclear translocation under metabolic stress, whereas metformin activates AMPK indirectly by inhibiting Complex I of the mitochondrial electron transport chain, and AICAR mimics AMP to trick the cell into AMPK activation

Many of these new substances appear so fast and with little efficacy support in the literature making it difficult for anti-doping authorities to properly evaluate and consider if they are a problem from the standpoint of performance enhancement