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Description

The response to acute focal TBI with tissue damage develops in the following phases: (i) cell death and inflammation, (ii) cell proliferation, tissue replacement with fibrotic scar and wound closure and (iii) tissue remodelling and neuroplasticity aimed at restoration and functional compensation 26,160 (Fig

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iPLA2-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4

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