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-syn aggregation leads to increased iron deposition and ferroptosis in PD mice, while MT1 knockout reduces the resistance of neurons to ferroptosis by inhibiting the SIRT1/Nrf2/HO-1/GPX4 pathway and inhibiting the expression of ferritin FTH1, resulting in more ferrous ion release, which further leads to more DA neuron loss and severe dyskinesia

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Peptide-spectra matches were then grouped based on protein ID, excluding peptides with summed reporter ion intensities for the WT channels 0.5, non-unique or non-tryptic peptide sequences

By bridging mitochondrial biology with infection immunology, this field holds transformative potential for managing infectious diseases and improving clinical outcomes