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Nuclear Transcription Factor Activation: Tracking the stimulation of native, cell-autonomous cytoprotective loops and anti-oxidant responses responsible for re-establishing immune homeostasis

Etiologic Factors of Gastroesophageal Reflux Disease Motility disorders Transient lower esophageal relaxationsa Weak lower esophageal sphinctera Weak esophageal peristalsis Etiology Gastroesophageal reflux results from several factors that lead to symptoms or injury of the esophageal mucosa by reflux of corrosive material from the stomach (Box 1.1)

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