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Treatment with febuxostat did not reduce significantly the progression renal disease, with a fall in eGFR in the placebo group of (-0.47 4.48 ml/min/1.73 m2) vs 0.23 5.26 ml/min/1.73 m2 in the febuxostat group

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Smoking impairs wound healing through vasoconstriction, reduced oxygen delivery, and impaired immune function