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6a, b) Delaying G6PDi-1 treatment for 1 h post-stimulation allowed for substantial cytokine production, indicating that G6PD and the PPP likely play an important role in the early signaling events following stimulation

In addition, activated B cells in RA patient peripheral blood drive inflammatory T helper cell activation and cytokine production via the ICOS-ICOSL pathway, while concomitantly upregulating T cell Glut1 expression to enhance glucose uptake (155)