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Frequently present at the onset of the disease, they persist throughout its course, even during periods of remission

ROLE OF EXTERNAL TRIGGERS While anti-ageing supplements alone may not be the cause, Dr Trehan acknowledges they can act as triggers, especially in individuals with existing but undiagnosed vulnerabilities

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Phosphorylation of T 495 residue on eNOS, which has traditionally been shown as a regulatory site inhibiting eNOS-derived nitric oxide production while promoting eNOS uncoupling and superoxide formation, was increased in animals who received PAGln (Supplementary Fig