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A study involving individuals undergoing hemodialysis found that after six weeks of taking 3 mg of melatonin before bedtime, cognitive function significantly improved, with the Montreal Cognitive Assessment score increasing from 21.19 to 24.27 in the intervention group, compared to 22.15 in the control group [223]

The underlying mechanisms are subject to continued scrutiny and are likely to be complex

Under pathological conditions, long-term excessive stress can cause damage to the endoplasmic reticulum function, and endoplasmic reticulum stress activates the apoptosis pathway, which leads to nerve cell damage and even death (Xuan et al., 2020)

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