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Animals The study was conducted with male Albino Wistar rats, bodyweight 200 g, 13 weeks old, in-house bred at the animal facility of the Department of Pharmacology, School of Medicine, Zagreb, Croatia

High therapeutic dosages, frequent administration, significant presystemic metabolism (first-pass effect), enzymatic breakdown, organ toxicity, and limited brain availability owing to the blood-brain barrier (BBB) are some of the challenges that these therapies face [9]

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