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This imbalance attenuates endogenous protective mechanisms, ultimately disrupting ovarian iron homeostasis and amplifying lipid peroxidation damagea cascade that may contribute to the follicular dysfunction characteristic of PCOS

A power analysis ( = 0.05 and power = 0.90), based on data where a difference would be significant if the weight loss were 1 kg more than that in CT group with an expected standard deviation of 0.75, indicated that 13 patients would be needed in each group to detect significant difference [18]

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