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The presence of GSH in W303-1b/gsh1/pro1 was about 4 % of wt level (Fig

13a, Supplementary Table 9), suggesting that the distinct rotamer orientation of H296 ECL2 in Cagri-bound CTR (to accommodate the Glu linker) and/or the observed more open ECL3 conformation induced by the lipidated peptide may facilitate or stabilize an active CTR conformation (Supplementary Fig

Studies show Epithalon enhances expression of antioxidant response element (ARE)-regulated genes, leading to increased synthesis of protective proteins and enzymes

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